Friday, July 8, 2016

Synaptic pruning


You might find this interesting.

...Researchers are just starting to unravel this mystery, but what they do know is the synaptic connections that get used less get marked by a protein, C1q (as well as others). When the microglial cells detect that mark, they bond to the protein and destroy—or prune—the synapse...


Have you ever felt like your brain is full? Maybe when starting a new job, or deep in a project. You're not sleeping enough, even though you're constantly taking in new information. Well, in a way, your brain actually is full.

When you learn lots of new things, your brain builds connections, but they're inefficient, ad hoc connections. Your brain needs to prune a lot of those connections away and build more streamlined, efficient pathways. It does that when we sleep.

Your brain cleans itself out when you sleep—your brain cells shrinking by up to 60% to create space for your glial gardeners to come in take away the waste and prune the synapses.

Have you ever woken up from a good night's rest and been able to think clearly and quickly? That's because all the pruning and pathway-efficiency that took place overnight has left you with lots of room to take in and synthesize new information—in other words, to learn...


And in fact, you actually have some control over what your brain decides to delete while you sleep. It's the synaptic connections you don't use that get marked for recycling. The ones you do use are the ones that get watered and oxygenated. So be mindful of what you're thinking about.

If you spend too much time reading theories about the end of Game of Thrones and very little on your job, guess which synapses are going to get marked for recycling?


If I esteem mankind to be in error, shall I bear them down? No. I will lift them up, and in their own way too, if I cannot persuade them my way is better; and I will not seek to compel any man to believe as I do, only by the force of reasoning, for truth will cut its own way.

I could not love thee, dear, so much,
Loved I not Honor more.

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